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Safe Glass Pressure Q-Tube and QianCap For Your Chemical Research

Regioselective ketone α-alkylation with simple olefins via dual activation
Fanyang Mo, Prof. Guangbin Dong, Science 4 July 2014, Vol. 345 no. 6192 pp. 68-72
link to the paper

Q-Tube assisted MCRs for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Luca Sancineto, Bonifacio Monti, Orsola Merlino, Ornelio Rosati, and Claudio Santib. Arkivoc 2018, part III, 270-278

Organic Reactions under High Pressure: Efficient Multicomponent Synthesis of Novel Tricyclic Pyridazinonaphthyridine
Derivatives under High Pressure
Moustafa, Moustafa S.; Al-Mousawi, Saleh M. Current Organic Chemistry, Volume 22, Number 3, January 2018, pp. 268-275(8)

Oxidation of aromatic oxygenates for the production of terephthalic acid
Konstantinos A.Goulas, Mika Shiramizu, James R.Lattner, Basudeb Saha, Dionisios G.Vlachos. Applied Catalysis A: General, Volume 552,
25 February 2018, Pages 98-104

The Q-tube System, A Nonconventional Technology for Green Chemistry Practitioners
Nacca, Francesca G.; Merlino, Orsola; Mangiavacchi, Francesca; Krasowska, Dorota; Santi, Claudio; Sancineto, Luca. Current Green
Chemistry, Volume 4, Number 2, August 2017, pp. 58-66(9)

Mechanism and kinetics of 1-dodecanol etherification over tungstated zirconia
Julie Rorrer, Ying He, F. Dean Toste, Alexis T.Bell. Journal of Catalysis, Volume 354, October 2017, Pages 13-23

Multi Component Reactions under Increased Pressure: On the Mechanism of Formation of Pyridazino[5,4,3-de]
[1,6]naphthyridine Derivatives by the Reaction of Malononitrile, Aldehydes and 2-Oxoglyoxalarylhydrazones in Q-Tubes
Majdah A. AL-Johani, Khadijah M. Al-Zaydi, Sameera M. Mousally, Norah F. Alqahtani, Noha Hilmy Elnagdi and Mohamed H. Elnagdi,
Molecules 2017, 22(12), 2114

Hydroxyl Radicals via Collision-Induced Dissociation of Trimethylammonium Benzyl Alcohols
Moore, Peter W., Hooker, Jordan P., Zavra, Athanasios, Khairallah, George N., Krenske, Elizabeth H., Bernhardt, Paul V., Quach, Gina, Moore,
Evan G., O’Hair, Richard A. J. and William, Craig M.
Australian Journal of Chemistry, 70 4: 397-406

Methods for producing fuels, gasoline additives, and lubricants
Eric SACIA, Anbarasan PAZHAMALAI, Balakrishnan MADHESAN, Sanil Sreekumar,F. Dean Toste, Amit A. Gokhale, Martin E. Carrera, Alexis T.
Bell, Gorkem GUNBAS
. US Patent 9738617B2

Integrated catalytic sequences for catalytic upgrading of bio-derived carboxylic acids to fuels, lubricants and chemical
Sankaranarayanapillai Shylesh, Amit A. Gokhale, Keyang Sun, Adam M. Grippo, Deepak Jadhav, Alice Yeh, Christopher R. Ho and Alexis T.
. Sustainable Energy Fuels, 2017, 1, 1805-1809

NATHANIEL BRACKETT. https://etd.ohiolink.edu/!etd.send_file?accession=wright1503673136761061&disposition=inline

DANIEL K. GREENE. https://etd.ohiolink.edu/!etd.send_file?accession=wright1513941221837164&disposition=inline

1H-Indole-3-carboxaldehyde: Synthesis and Reactions
Eslam El-Sawy; Heba Abo-Salem; Adel Mandour. Egyptian Journal of Chemistry, Article 1, Volume 60, Issue 5, September and October
2017, Page 723-751

Demulsification of Water-in-Heavy Crude Oil Emulsion using Amphiphilic Ammonium Salts as Demulsifiers
Juan de la Cruz ClavelJuan C. NavarroRafael Martínez-Palou. Tenside Surfactants Detergents: Vol. 54, No. 4, pp. 361-364.

Method to convert fermentation mixture into fuels
F. Dean Toste, Pazhamalai Anbarasan, Joseph B. BINDER, Paul A. Willems, Douglas S. Clark, Zach Baer, Sanil Sreekumar, Harvey W. Blanch.
US Patent 9856427B2

New phenylazetidinecarboxylate or -carboxamide compounds
Benaissa Boubia, Christine Massardier, Fabrice Guillier, Olivia Poupardin, Mireille Tallandier, Jerome Amaudrut, Michel Bondoux, Roelof
Williem FEENSTRA, Maria Johana Petronella VAN DONGEN
. US20170066717A1

Heteroaryl amides as inhibitors of protein aggregation
Wolfgang Wrasidlo, Emily M. Stocking. US20180093979A1

Synergistic Effects in Bimetallic Palladium–Copper Catalysts Improve Selectivity in Oxygenate Coupling Reactions
Konstantinos A. Goulas, Sanil Sreekumar, Yuying Song, Purnima Kharidehal, Gorkem Gunbas, Paul J. Dietrich, Gregory R. Johnson, Y. C.
Wang, Adam M. Grippo, Lars C. Grabow, Amit A. Gokhale, and F. Dean Toste
. J. Am. Chem. Soc., 2016, 138 (21), pp 6805–6812

Nanostructured photoelectrochemical solar cell for nitrogen reduction using plasmon-enhanced black silicon
Muataz Ali, Fengling Zhou, Kun Chen, Christopher Kotzur, Changlong Xiao, Laure Bourgeois, Xinyi Zhang & Douglas R. MacFarlane. Nature
Communications 7, Article number: 11335 (2016)

Use of a novel multicomponent reaction under high pressure for the efficient construction of a new pyridazino[5,4,3-de][1,6]
naphthyridine tricyclic system
Moustafa Sherief Moustafa,   Saleh Mohammed Al-Mousawia and   Mohamed Hilmy Elnagdib  . RSC Adv., 2016,6, 90840-90845

Multicomponent reactions in Q-Tubes: one-pot synthesis of benzo[c]chromen-6-one and phenanthridin-6(5H)-one derivatives in
a four-component reaction
Khadijah M. Alzaydia,, Nagat S. Abojabala, Mohamed Hilmy Elnagdib. Tetrahedron Letters, Volume 57, Issue 32, 10 August 2016, Pages

Co-production of acetone and ethanol with molar ratio control enables production of improved gasoline or jet fuel blends
Baer ZC, Bormann S, Sreekumar S, Grippo A, Toste FD, Blanch HW, Clark DS. Biotechnology and Bioengineering, 2016 Oct;113(10):

Pressure as effective green technology for synthesis of polyfunctionally substituted heteroaromatics: Synthesis of a variety of
Douaa Salman AlMarzouq, Omniya Sayed Zaky, Abdulaziz Abdulrazaq AlNajjar, Kamal Usef Sadek
European Journal of Chemistry 2016, 7(3), 347-351

Feasibility of Using 2,3,3,3-Tetrafluoropropene (R1234yf) as a Solvent for Solid-Liquid Extraction of Biopharmaceuticals
John Suberu, Peyman Yamin, Robert Cornell, Arya Sam, and Alexei Lapkin. ACS Sustainable Chem. Eng. 2016, 4, 2559-2568

Production of an ​acetone-​butanol-​ethanol mixture from Clostridium acetobutylicum and its conversion to high-value biofuels
S Sreekumar, ZC Baer, A Pazhamalai, G Gunbas, A Pazhamalai, G Gunbas, A Grippo, H Blanch, D S Clark & F D Toste. Nature Protocols
10, 528–537 (2015)

Bio-based polymer networks by thiol–ene photopolymerizations of allyl-etherified eugenol derivatives
T Yoshimura, T Shimasaki, N Teramoto, M Shibata. European Polymer Journal, Vol 67, June 2015, Pages 397–408

Highly Selective Condensation of Biomass‐Derived Methyl Ketones as a Source of Aviation Fuel
ER Sacia, M Balakrishnan, MH Deaner, KA Goulas, Prof. F. D Toste and Prof. A. T. Bell
ChemSusChem, Vol. 8, Issue 10, pages 1726–1736, May 22, 2015

Concise synthesis of 12a-methyl-11-aryl-1, 2-dihydrobenzo [f] pyrrolo [1, 2-a] quinolin-3 (12aH)-ones as racemic 14-azaestrogen
AM Abdelkhalik, NK Paul, A Jha. Steroids, Vol. 98, June 2015, Pages 107–113

Synthesis and characterization of mackinawite nanocrystals (FeSm) and their application in recovery of aqueous Hg (II) solution
SM Alshehri, A Aldalbahi, T Ahamad, N Alhokbany. Desalination and Water Treatment, Vol. 55, Issue 12, 2015

Compositions and kits for diagnosing infections
G Timmins, T Wu, SW Choi. US Patent App. 14/596,926, 2015

E Altmann, U Hommel, ELJ Lorthiois. US Patent App. 14/409,911, 2015

Novel pathways for fuels and lubricants from biomass optimized using life-cycle greenhouse gas assessment
M Balakrishnan, E Sacia, S Sreekumara, G Gunbasa, A Gokhalea, C Scowna, F. D Toste and A. T. Bell. PNAS, June 23, 2015, vol. 112 no.

Upgrading Lignocellulosic Products to Drop‐In Biofuels via Dehydrogenative Cross‐Coupling and Hydrodeoxygenation
S Sreekumar, M Balakrishnan, K Goulas, G Gunbas, A. Gokhale, L Louie, A Grippo, C Scown, Prof. A T. Bell, Prof.  F. D Toste
ChemSusChem, Vol. 8, Issue 16, pages 2609–2614, August 24, 2015

The twin drug approach for novel nicotinic acetylcholine receptor ligands
Isabelle Tomassoli, Daniela Gündisch
Bioorganic & Medicinal Chemistry
Vol. 23, Issue 15, 1 August 2015, Pages 4375–4389

A New Route to the Versatile Synthesis of Thiopyrano [2, 3-b: 6, 5-b'] diindoles via 2-(Alkylthio)-indole-3-carbaldehydes
M Jha, M Edmunds, K Lund, A Ryan. Tetrahedron Letters, Volume 55, Issue 41, 8 October 2014, Pages 5691–5694

Chemocatalytic Upgrading of Tailored Fermentation Products Toward Biodiesel
Dr. S.Sreekumar, Z.C.Baer, Dr. E.Gross, Dr. S. Padmanaban, K.Goulas, G.Gunbas, Dr. S Alayoglu,Prof. Harvey W. Blanch, Prof. Douglas S.
Clark and Prof. F. Dean Toste
. ChemSusChem 15 July 2014, Vol. 7, Issue 9

High-performance bio-based thermosetting resins based on bismaleimide and allyl-etherified eugenol derivatives
M Neda, K Okinaga, M Shibata. Materials Chemistry and Physics, Volume 148, Issues 1–2, 14 November 2014, Pages 319–327

Engineering Clostridium acetobutylicum for production of kerosene and diesel blendstock precursors
S.Bormanna, Z.C.Baer, S.Sreekumar, J.M. Kuchenreuthera, F.Dean Toste, Harvey W. Blanch, Douglas S. Clark. Metabolic Engineering,
Volume 25, September 2014, Pages 124–130

Non-Conventional Methodologies in the Synthesis of 1-Indanones
M.Oliverio, M.Nardi, P.Costanzo, L.Cariati, G.Cravotto, S.V.Giofrè and A.Procopio. Molecules 2014, 19, 5599-5610

Facile Ecofriendly Synthesis of Monastrol and Its Structural Isomers via Biginelli Reaction
M.Oliverio, P.Costanzo, M.Nardi, I.Rivalta, and A.Procopio. ACS Sustainable Chemistry & Engineering, 2014

"Discovery of Dap-3 Polymyxin Analogs for the Treatment of Multidrug-Resistant Gram-negative Nosocomial Infections"
Thomas V. Magee, Matthew F. Brown, Jeremy T. Starr, et al. J. Med. Chem. 2013, 56, 5079−5093

"Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and
antibacterial agents"
Dianqing Sun, et al. The Journal of Antibiotics (2013) 66, 319–325

"Bronsted acid-catalyzed rapid enol-ether formation of 2-hydroxyindole-3-carboxaldehydes"
D. Blanchard, TS Cameron, M. Jha - Molecular Diversity, 17: 827-834, 2013 - Springer

"Palladium-Catalysed Dehydrogenative Generation of Imines from Amines. A Nature-Inspired Route to Indoles via Cross-
Couplings of Amines with Arylhydrazines"
Maurizio Taddei, Manuel G. Mura, Suvi Rajamäki.
Advanced Synthesis & Catalysis, Vol. 355, Issue 14-15, pages 3002–3013, October 11, 2013

"Bio-based thermosetting bismaleimide resins using eugenol, bieugenol and eugenol novolac"
Mitsuhiro Shibata, Naozumi Tetramoto, Ayumi Imada. Reactive and Functional Polymers, Vol. 73, Issue 8, August 2013, Pages 1086–1095

"Efficient synthesis of ionic liquids/precursors using a Q-Tube (TM)."
Krol, M. Joseph, Andrew Beauchamp, and William A. Feld. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. Vol. 245.

"Inhibitors of influenza viruses replication"
Paul S. Charifson, Michael P. Clark, et al. US 20130345218 A1

"Rollover Cyclometalation Pathway in Rhodium Catalysis: Dramatic NHC Effects in the C−H Bond Functionalization"
Jaesung Kwak, Youhwa Ohk, Yousung Jung, and Sukbok Chang, J. Am. Chem. Soc. 2012, 134, 17778−17788

"Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor
2 as Potential Tracers for Positron Emission Tomography Imaging"
José-Ignacio Andrés, Jesús Alcázar, JoséMaría Cid. J. Med. Chem. 2012, 55, 8685−8699

"Polymyxin Derivates Useful As Antibacterial Agents"
Magee, Thomas Victor, et al. U.S. Patent No. 20,120,316,105. 13 Dec. 2012.

"Imidazo[5,1-f][1,2,4]Triazines for the Treatment of Neurological Disorders"
homas A. Chappie, Christopher J. Helal, John M. Humphrey, U.S.  20120214791 A1

"Molecular Vibration-Sensing Component in Human Olfaction"  
Gane S, Georganakis D, Maniati K, Vamvakias M, Ragoussis N, et al. (2013) PLoS ONE 8(1): e55780.

"Diels-Alder Reactions of Dienophiles and Cyclopentadiene Using a Sealed Tube Protocol"
Richard T. Taylor*, Christopher M. Goins and Katherine R. Taylor, Miami University

"Preparation and characterization of rhenium(I) dicarbonyl complexes based on the meridionally-coordinated terpyridine
Daniel R. Black, Sean E. Hightower. Inorganic Chemistry Communications, Vol. 24, October 2012, Pages 16–19

"Synthesis of CdS Nanocrystals Using Polymer Metal Complex as a Single Source Precursor and their Physicochemical
Ahamad, Tansir, and Saad M. Alshehri. Nano Hybrids 1 (2012): 45-56.

"Double Schiff Base Adducts of 2,3-Butanedione with Glycine: Formation of Pyrazine Rings with the Participation of Amino Acid
Carbon Atoms."
Paula Vanessa Guerra and Varoujan A. Yaylayan. J. Agric. Food Chem., 2012, 60 (45), pp 11440–11445

"Role of the Ribose-Specific Marker Furfuryl-amine in the Formation of Aroma Active 1-(Furan-2-ylmethyl)-1H-pyrrole (or Furfuryl-
pyrrole Derivatives."                            
Plamen Y. Nikolov and Varoujan A. Yaylayan. J. Agric. Food Chem., 2012, 60 (40), pp 10155–10161

"Synthesis and Structure-Activity Relationships of Lansine Analogues as Antileishmanial Agents."
Pieroni, Marco, et al. ChemMedChem (Vol.7, 1895-1900, 2012).
About Us

Q Labtech is a U.S.-based laboratory technology company. Our patented technology features a pressure-release and reseal system that
prevents accidental explosions due to over pressurization in the pressure reactor. Our products, Q-Tube (pressure reactor) and QianCap
(safety cap for Ace type pressure bottles), are affordable alternatives to microwave synthesizers. Our Fisher-Porter type of purging systems
can be used for hydrogenation and gas-filled pressurized reactions.  

How Does Pressure Impact Chemical Reactions?

A pressure reactor enables a reaction to be carried out at higher temperature than the boiling point of a solvent and a reagent, which will
increase the reaction rate (Arrhenius Equation: every 10°C increase could double the speed). Pressure reduces reaction volume, including
liquid, which increases concentration and collision frequency, and in turn speeds up a reaction. When the desired reaction is accelerated , the
competing reagent decompositions are minimized. Pressure enables faster reactions with cleaner profiles.

The Benefits of Our Products

Q-Tube™ and QianCap™ PURGING systems can be operated safely and accurately with high reproducibility with a wide range of gases,
including Ammonia, Nitrogen, Argon, Hydrogen, Deuterium, Carbon Monoxide, Carbon Dioxide, etc.

Q-Parallel Synthesizer™ enable multiple simultaneous reactions to be done in about 40 minutes; a great tool for reaction optimization and
pressurized parallel synthesis.

Q-Tube-12mL and 35mL pressure reactors are affordable alternatives to expensive and cumbersome microwave synthesizers. In addition to
organic synthesis, Q-Tube™  and QianCap™ find use anywhere that higher yields, cleaner products, and synthesis, catalytic hydrogenation,
polymerization, acid digestion process for accurate trace metal analysis, like silver, and other chemical processes.

In addition to the above benefits using the Q-TUBE™ and QianCap™ overa microwave synthesizer, Q-TUBE™ and QianCap™ provide extra
advantages of:

  • Safety-virtually eliminating the risk of pressure explosions
  • Higher and cleaner product yields (microwave energy is known to cause localized overheat which accelerates decomposition reactions
    especially on heterocycles)
  • Scalable (up to 1850 mL)
  • Higher Pressure than a typical pressure tube
  • Higher reproducibility (than a microwave)
  • Greener (broader solvent choices than microwave and conventional round bottom flask)
  • Energy savings (92 percent energy reduction and 150 gallons of water per refluxed reaction)
  • Affordable, only a fraction of a microwave synthesizer
  • Maintenance-free